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Description of biometrological alterations

Atopic dermatitis, psoriasis and ichthyoses and improvement in case of use of an emollient based on vaseline-glycerol

The stratum corneum barrier is commonly described according to the "brick and mortar" model constituted respectively by corneocytes and intercellular lipids: the former are composed mainly by insoluble bundled keratins surrounded by a cell envelope stabilized by cross-linked proteins and covalently bound lipids. Polar structures, such as corneodesmosomes, interconnect corneocytes determining stratum corneum cohesion. Intercorneocytic lipids are primarily generated from exocytosis of lamellar bodies during the keratinocytes terminal differentiation and secondarily generated by sebaceous output. Lipids are required for a competent skin barrier and homeostatic control of transcutaneous penetration (1).

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